Xylazine 100 mg/mL Injection

Analgesic, sedative and muscle relaxant for use in horses.

 

Size: 50 mL vial

Technical Note Safety Sheet

Dosage and Administration

Use the contents within 3 months of first broaching the vial. Discard the unused portion.

Horses

Vary dosage schedule according to circumstances and depth and duration of sedation required.
Intravenous administration usually gives a more rapid onset of effect, but the duration is shorter than with intramuscular administration.
Xylazine may be used alone or combined with other sedatives, analgesics and anaesthetics to produce the desired effect from mild sedation to heavy
sedation to (in combination with ketamine) full surgical anaesthesia.

Mild Sedation  Intravenous (slow): 0.25 - 0.5 mL per 100 kg bodyweight (0.25 - 0.5 mg per kg).
Heavy Sedation 

Intravenous (slow): 1.1 mL per 100 kg bodyweight (1.1 mg per kg).

Intramuscular: 2.2 mL per 100 kg bodyweight (2.2 mg per kg).
Spasmodic Colic

Xylazine may be used as a sedative/analgesic in spasmodic (hypermotility) colic. However, it is contraindicated in cases of obstructive colic or ileus as xylazine will further reduce gut motility. In early stages of presentation of colic, it may be difficult to differentiate between spasmodic colic and one that will progress to obstructive colic. Therefore, considerable care should be taken in diagnosis and alternative analgesia used if diagnosis is in doubt.

Intravenous (slow): 0.5 mL per 100 kg bodyweight (0.5 mg per kg). This dose will provide analgesia for about 20 minutes. Other α-2 adrenoceptor agonists, may provide more powerful and longer lasting sedation and analgesic effects. In cases of moderate to severe spasmodic colic, profound analgesia can be achieved by combining butorphanol with xylazine (0.5 mg per kg).

 

Active Constituent(s)

Xylazine (as hydrochloride) 100 mg/mL

Contraindications

This product is contraindicated in the following situations:
  • Intra-arterial administration
  • Use in horses with obstructive colic or ileus
  • Use in mares in last trimester of pregnancy
  • Concurrent administration with adrenaline

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